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Home / Primary Antibodies / IHC Antibodies

Anti-RAP1GAP Antibody BHA11303092

SKU : BHA11303092

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Mfr.No.	BS5883
Alternative Names	Rap1 GTPase-activating protein 1 ; Rap1GAP ; Rap1GAP1 ; KIAA0474 ; RAP1GA1
Antigen	Rap1GAP
Categories	Primary Antibodies
Chromosome Location	1p36.12
Clonality	polyclonal
Description	Rap1 GTPase activating protein (Rap1GAP) specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1. Physical interaction between Gα z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the α subunit, and also attenuates the ability of activated Gα z to inhibit adenylyl cyclase. Rap1GAP is expressed in the brain, kidney and pancreas and may act as a signal integrator to coordinate and/or integrate Gz signaling and Rap1 signaling in cells. A novel isoform of Rapl GTPase-activating protein, designated Rap1GAPII, binds specifically to Gα z. Stimulation of the Gi-coupled M2 Muscarinic receptor translocates Rap1GAPII from the cytosol to the membrane and decreases the amount of GTP-bound Rap1, resulting in the activation of ERK/MAPK.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to the 525-570 of Human RAP1GAP.
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P47736
Uniprot	P47736
Weight	73, 89 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: RAP1GAP polyclonal antibody detects endogenous levels of RAP1GAP protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303092	BS5883	50µl	$190.44		Add to Cart
BHA11303092	BS5883	100µl	$294.44		Add to Cart

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