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Home / Primary Antibodies / IHC Antibodies

Anti-RAN Antibody BHA11300472

SKU : BHA11300472

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Mfr.No.	BS1308
Alternative Names	GTP-binding nuclear protein Ran ; Androgen receptor-associated protein 24 ; GTPase Ran ; Ras-like protein TC4 ; Ras-related nuclear protein ; ARA24 ; OK/SW-cl.81
Antigen	Ran
Categories	Primary Antibodies
Chromosome Location	12q24.33
Clonality	polyclonal
Description	The small Ras-related protein Ran, also called TC4, is a 24 kDa, nuclear localized GTPase implicated in a diverse array of cellular processes including DNA replication, entry into and exit from mitosis and the transport of RNA and proteins through the nuclear pore complex. Like Ras, active Ran GTP and inactive Ran GDP levels are tightly regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). The abundant GEF, RCC1 (regulator of chromosome condensation 1), increases the rate at which Ran exchanges GDP for GTP. Ran GAP1 opposes the effects of RCC1 by increasing the rate at which Ran hydrolyzes GTP to GDP. A 23 kDa protein designated Ran BP1 has no intrinsic GAP activity, and functions as a GEF inhibitor deactivating RCC1 and thereby indirectly increasing the ratio of Ran GDP to Ran GTP. The 358 kDa protein Ran BP2 has been proposed as the Ran GTP docking site at the periphery of the nuclear pore complex.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 170-200 of Human RAN.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P62826
Uniprot	P62826
Weight	26 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: RAN (E202) polyclonal antibody detects endogenous levels of RAN protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300472	BS1308	50µl	$190.44		Add to Cart
BHA11300472	BS1308	100µl	$294.44		Add to Cart

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