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Home / Antibodies

Anti-PVALB Antibody BHA11304191

SKU : BHA11304191

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Mfr.No.	BS61332
Alternative Names	Parvalbumin alpha ; PVALB
Categories	Primary Antibodies
Chromosome Location	22q12.3
Clonality	polyclonal
Description	The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100α and β, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins) and the parvalbumin family members, including parvalbumin α and parvalbumin β, also designated oncomodulin (OCM). Structurally and evolutionarily conserved, parvalbumin α and OCM proteins are distinct in expression and function. Parvalbumin α, also designated parvalbumin (PV), is most abundantly expressed in fast-contracting muscles with lower expression levels in brain and some endocrine tissues, including kidney and parathyroid. Research indicates that parvalbumin α plays a significant role in muscle relaxation. OCM was originally thought to have expression restricted to neoplastic tissues, early embryonic cells and certain tumor cell lines. Recent research shows that OCM is also expressed and secreted by macrophages where, in the retina it binds to retinal ganglion cells (RGCs) and functions to promote axon regeneration. OCM has also been detected in the auditory sensory cells of the organ of Corti in mammals. In humans, two different loci on chromosome 7 have been identified as OCM and OCM-like (LOC4951). These genes encode proteins 109 amino acids in length which share 99% sequence identity.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human PVALB.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P20472
Uniprot	P20472
Weight	12 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: PVALB polyclonal antibody detects endogenous levels of PVALB protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304191	BS61332	50µl	$190.44		Add to Cart
BHA11304191	BS61332	100µl	$294.44		Add to Cart

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