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Home / Antibodies

Anti-PPP1R13B Antibody BHA11303949

SKU : BHA11303949

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Mfr.No.	BS60843
Alternative Names	Apoptosis-stimulating of p53 protein 1 ; Protein phosphatase 1 regulatory subunit 13B ; PPP1R13B ; ASPP1 ; KIAA0771
Antigen	PPP1R13B
Categories	Primary Antibodies
Chromosome Location	14q32.33
Clonality	polyclonal
Description	ASPP proteins interact with p53 and are responsible for enhancing p53-induced apoptosis but not cell cycle arrest. Inhibition of endogenous ASPP1 (PPP1R13B) function inhibits the apoptotic function of endogenous p53 in response to apoptotic stimuli. ASPP1 amplifies DNA binding and transactivation function of p53 on the promoters of proapoptotic genes in vivo. Expres-sion of ASPP1 is often downregulated in human breast carcinomas expressing wildtype p53, but not in those expressing mutant p53. This research indicates that ASPP1 regulates the tumor suppression function of p53 in vivo. ASPP1 is predominantly a cytoplasmic protein, although some fraction of the polypeptide is nuclear. Defects in PPP1R13B, the gene which encodes ASPP1, may be a cause of breast cancers. The deduced ASPP1 protein contains 1,090 amino acid residues.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human PPP1R13B.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q96KQ4
Uniprot	Q96KQ4
Weight	119 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.4. Specificity: PPP1R13B polyclonal antibody detects endogenous levels of PPP1R13B protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -21°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303949	BS60843	50µl	$190.44		Add to Cart
BHA11303949	BS60843	100µl	$294.44		Add to Cart

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