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Home / Antibodies

Anti-PLCG2 Antibody BHA11304160

SKU : BHA11304160

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Mfr.No.	BS61288
Alternative Names	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC:3.1.4.11) ; Phosphoinositide phospholipase C-gamma-2 ; Phospholipase C-IV ; PLC-IV ; Phospholipase C-gamma-2 ; PLC-gamma-2 ; PLCG2
Categories	Primary Antibodies
Chromosome Location	16q24.1
Clonality	polyclonal
Description	Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.There are many mammalian PLC isozymes, including PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1, PLC δ2 and PLC ε. After stimulation of the collagen receptor glycoprotein VI in human platelets, PLC γ2 associates with several tyrosine-phosphorylated proteins (Syk, SLP-76, Lyn, linker for activation of T cells (LAT) and the FcR γ chain), which bind to its C-terminal SH2 domain. PLC γ1 associates with Syk in B cells, but PLC γ2 does not associate with Syk in platelets. The C-terminal SH2 domain is involved in the regulation of PLC γ2. In addition, Btk can induce PLC γ2 tyrosine phosphorylation and initiate calcium moblization in CD72-stimulated B lymphocytes.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human PLC γ2.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P16885
Uniprot	P16885
Weight	148 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: PLC γ2 polyclonal antibody detects endogenous levels of PLC γ2 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304160	BS61288	50µl	$190.44		Add to Cart
BHA11304160	BS61288	100µl	$294.44		Add to Cart

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