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Home / Antibodies

Anti-PEA15 Antibody BHA11304225

SKU : BHA11304225

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Mfr.No.	BS61435
Alternative Names	Astrocytic phosphoprotein PEA-15 ; 15 kDa phosphoprotein enriched in astrocytes ; Phosphoprotein enriched in diabetes ; PED ; PEA15
Antigen	PEA15
Categories	Primary Antibodies
Chromosome Location	1q23.2
Clonality	polyclonal
Description	PEA-15 (Phosphoprotein Enriched in Astrocytes) exists in an non-phosphorylated form (N), and two phosphorylated forms, Pa and Pb. PEA-15 is an endogenous substrate for PKC, which mediates the transition from Pa to Pb. The level of PEA-15 phosphorylation changes upon depolymerization or stabilization of tubulins, indicating that PEA-15 colocalizes with microtubules. The first 80 amino acids of PEA-15 correspond to the death effector domain (DED), which is a domain found in proteins that regulate apoptotic signaling pathways. The DED domain is necessary for PEA-15 to block Ras suppression. Although PEA-15 is predominantly expressed in the central nervous system, low levels of PEA-15 are expressed in liver and kidney, and higher levels in muscle. PEA-15 is also referred to as PED, Phosphoprotein Enriched in Diabetes, for its elevated expression in type 2 diabetic patients.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 85-130 of Human PEA15.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q15121
Uniprot	Q15121
Weight	15 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: PEA15 polyclonal antibody detects endogenous levels of PEA15 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304225	BS61435	50µl	$190.44		Add to Cart
BHA11304225	BS61435	100µl	$294.44		Add to Cart

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