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Home / Antibodies

Anti-N4BP2L2 Antibody BHA11303061

SKU : BHA11303061

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Mfr.No.	BS5850
Alternative Names	NEDD4-binding protein 2-like 2 ; Phosphonoformate immuno-associated protein 5 ; CG005 ; PFAAP5
Antigen	N4BP2L2
Categories	Primary Antibodies
Chromosome Location	13q13.1
Clonality	polyclonal
Description	N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein that potentially is involved in transcriptional regulation. N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, probably by ATM or ATR. Primarily expressed in bone marrow, N4BP2L2 is dramatically down-regulated after exposure to arsenic compounds, an event which precedes neutropenia. PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, two proteins that are implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase, ELA2, are the cause of cyclic haematopoiesis, which, with decreased numbers of circulating neutrophils, leads to an increased risk for opportunistic infection.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 400-445 of Human N4BP2L2.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q92802
Uniprot	Q92802
Weight	67 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: N4BP2L2 polyclonal antibody detects endogenous levels of N4BP2L2 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303061	BS5850	50µl	$190.44		Add to Cart
BHA11303061	BS5850	100µl	$294.44		Add to Cart

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