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Home / Antibodies

Anti-MOB2 Antibody BHA11303223

SKU : BHA11303223

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Mfr.No.	BS60058
Alternative Names	MOB kinase activator 2 ; Mob2 homolog ; Mps one binder kinase activator-like 2 ; MOB2 ; HCCA2
Antigen	MOB2
Categories	Primary Antibodies
Clonality	polyclonal
Description	HCCA2 (Hepatocellular carcinoma-associated gene 2), also known as MOB2 (Mps one binder kinase activator-like 2), is a 467 amino acid protein that belongs to the MOB1/phocein family. HCCA2 is expressed in lung, spleen, brain, and fetal liver. It is highly expressed in hepatocellular carcinoma. HCCA2 is localized in the perinuclear region of the cytoplasm in liver cancer tissues and colocalizes with MAD2L2 in the nucleus of Hela cells. HCCA2 is chracaterized by two N-glycosylation sites, six N-myristolylation sites, two Src homolgy 3 (SH3), and several phosphorylation motifs which indicate that this protein may play a role in an intracellular signal transduction cascade. HCCA2 binds to and regulates the autophosphorylation of the related human serine/threonine kinase 38 (NDR1) and serine/threonine kinase 38L (NDR2). It has been shown that HCCA2 plays a critical role in cell cycle regulation. Overexpression of the protein during the G0/G1 phase inhibits cell proliferation causing cell cycle arrest.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human HCCA2.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q70IA6
Uniprot	Q70IA6
Weight	28 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: HCCA2 polyclonal antibody detects endogenous levels of HCCA2 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303223	BS60058	50µl	$190.44		Add to Cart
BHA11303223	BS60058	100µl	$294.44		Add to Cart

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