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Home / Antibodies

Anti-MFGE8 Antibody BHA11303753

SKU : BHA11303753

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Mfr.No.	BS60623
Alternative Names	Lactadherin ; Breast epithelial antigen BA46 ; HMFG ; MFGM ; Milk fat globule-EGF factor 8 ; MFG-E8 ; SED1 ; MFGE8
Categories	Primary Antibodies
Chromosome Location	15q26.1
Clonality	polyclonal
Description	Human milk-fat globule (MFG) is abundant in human breast milk and is composed of secreted lipids encapsulated by plasma membranes from the epithelial cells of mammary glands. MFG membranes are composed of various glycoproteins that serve as markers for differentiated carcinomas. MFG-E8 (Milk fat globule-EGF factor 8), also known as Lactadherin or BA46, is a 387 amino acid peripheral membrane protein that localizes to the membrane of a variety of tissues, including mammary epithelial surfaces, and contains one EGF-like domain and two F5/8 type C domains. Functioning as a specific ligand for Integrin ∫5 and Integrin ∫3, MFG-E8 is thought to be involved in gamete interactions and cell attachment, possibly playing a role in fertilization and apoptosis. Additionally, MFG-E8 binds to rotavirus and inhibits its replication, thereby protecting the cell from viral infection. Overexpression of MFG-E8 is associated with breast cancer, suggesting that MFG-E8 may be related to tumorigenesis.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human MFGE8
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q08431
Uniprot	Q08431
Weight	43 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: MFGE8 polyclonal antibody detects endogenous levels of MFGE8 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303753	BS60623	50µl	$190.44		Add to Cart
BHA11303753	BS60623	100µl	$294.44		Add to Cart

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