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Home / Primary Antibodies / Recombinant Antibodies

Anti-MCM5 Antibody BHA11306393

SKU : BHA11306393

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Mfr.No.	BS7159
Alternative Names	DNA replication licensing factor MCM5 ; CDC46 homolog ; P1-CDC46 ; MCM5 ; CDC46
Antigen	MCM5
Categories	Primary Antibodies
Chromosome Location	22q12.3
Clonality	polyclonal
Description	The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation of the MCM complex (composed of at least MCM proteins 2–6) during apoptosis.
Host	Rabbit
Immunogen	Recombinant full length Human MCM5.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P33992
Uniprot	P33992
Weight	90 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: MCM5 polyclonal antibody detects endogenous levels of MCM5 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IF

Description

WB ; IF

Dilution

WB	1:1000-1:3000
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11306393	BS7159	50µl	$234.89		Add to Cart
BHA11306393	BS7159	100µl	$368.22		Add to Cart

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