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Home / Primary Antibodies / Recombinant Antibodies

Anti-IFIH1 Antibody BHA11305148

SKU : BHA11305148

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Mfr.No.	BS6939
Alternative Names	Interferon-induced helicase C domain-containing protein 1 ; Clinically amyopathic dermatomyositis autoantigen 140 kDa ; CADM-140 autoantigen ; Helicase with 2 CARD domains ; Helicard ; Interferon-induced with helicase C domain protein 1 ; Melanoma differentiation-associated protein 5 ; MDA-5 ; Murabutide down-regulated protein ; RIG-I-like receptor 2 ; RLR-2 ; RNA helicase-DEAD box protein 116 ; IFIH1 ; MDA5 ; RH116
Categories	Primary Antibodies
Chromosome Location	2q24.2
Clonality	polyclonal
Description	Antiviral innate immunity depends on the combination of parallel pathways triggered by virus detecting proteins in the Toll-like receptor (TLR) family and RNA helicases, such as Rig-I (retinoic acid-inducible gene I) and MDA-5 (melanoma differentiation-associated antigen 5), which promote the transcription of type I interferons (IFN) and antiviral enzymes. TLRs and helicase proteins contain sites that recognize the molecular patterns of different virus types, including DNA, single-stranded RNA (ssRNA), double-stranded RNA (dsRNA), and glycoproteins. These antiviral proteins are found in different cell compartments; TLRs (i.e. TLR3, TLR7, TLR8, and TLR9) are expressed on endosomal membranes and helicases are localized to the cytoplasm. Rig-I expression is induced by retinoic acid, LPS, IFN, and viral infection. Both Rig-I and MDA-5 share a DExD/H-box helicase domain that detects viral dsRNA and two amino-terminal caspase recruitment domains (CARD) that are required for triggering downstream signaling.
Host	Rabbit
Immunogen	Recombinant full length Human IFIH1.
Reactivity	Human, Mouse
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q9BYX4
Uniprot	Q9BYX4
Weight	117 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: IFIH1 polyclonal antibody detects endogenous levels of IFIH1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IF

Description

WB ; IF

Dilution

WB	1:500-1:2000
IF	1:50-1:200

Datasheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA11305148	BS6939	50µl	$234.89		Add to Cart
BHA11305148	BS6939	100µl	$368.22		Add to Cart

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