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Home / Primary Antibodies / Monoclonal Antibodies

anti-human CD272 (BTLA)

SKU : BHA14700154

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Ancell Corporation

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Mfr.No.	372, 372-020, 372-030, 372-040, 372-050, 372-820
Alternative Names	BTLA, B and T Lymphocyte Attenuator
Antigen	CD272 (BTLA)
Background	Human CD272 (BTLA, B and T Lymphocyte Attenuator) is a member of the Immunoglobulin superfamily and has sequence homology to PD-1 and CTLA4. It is expressed on T and B lymphocytes and other hemopoetic lineages. Engagement of this molecule by its ligand, CD270(HVEM, a TNF superfamily member) can down regulate activated T and B cell responses. CD272 levels on antigen specific CD8+ T cells have been reported to decrease in viral specific, but not melanoma specific activated lines (1). Polymorphism of the CD272 molecule has been linked to rheumatoid arthritis (3). Antibody from clone ANC5A5 binds to CD272 on the cell surface of human PBMC in Flow cytometry and to recombinant CD272-muIg (cat #542-020) in EIA. This antibody does not block binding of Biotinylated CD270(HVEM)-muIg(cat #531-030) to CD272-muIg in EIA, but appears to enhance this interaction. Antibodies ANC6E9(cat #272-020) and ANC5A5(cat #372-020) each bind a distinct epitope of CD272 and are suitable as a matched pair for EIA using ANC6E9 as capture and Biotinylated ANC5A5(cat# 372-030) as detector.
Formulation	50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate
Isotype	IgG1k
Reactivity	Human
Specificity	human

Purity	Antibody was Protein A purified from (low FBS containing) tissue culture supernatant. Purity was >95%Immunoglobulin by SDS-PAGE with less than 1% Bovine Immunoglobulin.
Storage	Store at 2 - 5°C. Freeze/Thawing is not recommended
Storage Buffer	50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5 mg/ml Gentamicin Sulfate (as a preservative).

Applications	EIA, FC

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Conjugate	Size	Your price	Quantity
BHA14700154-1	372-020	Pur WA	100 ug	$235		Add to Cart
BHA14700154-2	372-030	Biotin	100 ug	$325		Add to Cart
BHA14700154-3	372-040	FITC	120 tests	$325		Add to Cart
BHA14700154-4	372-050	PE	120 tests	$350		Add to Cart
BHA14700154-5	372-820	Pur/PF	100 ug	$235		Add to Cart

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