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Home / Antibodies

Anti-HLA-DQB2/HLA-DQB1 Antibody BHA11303706

SKU : BHA11303706

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Mfr.No.	BS60575
Alternative Names	HLA class II histocompatibility antigen, DQ beta 1 chain ; MHC class II antigen DQB1 ; HLA-DQB1 ; HLA-DQB ; HLA class II histocompatibility antigen, DQ beta 2 chain ; HLA class II histocompatibility antigen, DX beta chain ; MHC class II antigen DQB2 ; HLA-DQB2 ; HLA-DXB
Antigen	HLA-DQB2/HLA-DQB1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Destination of major histocompatibility complex (MHC) class II molecules for presentation to CD4+ helper T-cells is determined by two key events: the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, DQ, DP and DR) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. The alpha 1 chain of HLA-DQ1 class II molecule complex can bind peptides and present them to CD4+ T lymphocytes. HLA-DQB1 may be implicated in multiple sclerosis.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human HLA-DQB1/B2
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	P01920/P05538
Uniprot	P01920/P05538
Weight	30 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: HLA-DQB1/B2 polyclonal antibody detects endogenous levels of HLA-DQB1/B2 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303706	BS60575	50µl	$190.44		Add to Cart
BHA11303706	BS60575	100µl	$294.44		Add to Cart

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