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Home / Primary Antibodies / Recombinant Antibodies

Anti-GRK1 Antibody BHA11306069

SKU : BHA11306069

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Mfr.No.	BS7127
Alternative Names	Rhodopsin kinase ; RK ; EC=2.7.11.14 ; G protein-coupled receptor kinase 1 ; RHOK ; GRK1
Antigen	GRK1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messengerregulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1α and β); two forms of β-adrenergic receptor kinase: GRK 2 (βARK, βARK1) and GRK 3 (βARK2); IT-11 (GRK 4); GRK 5; GRK 6; and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
Host	Rabbit
Immunogen	Recombinant full length Human GRK1.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO

Swissprot	Q15835
Uniprot	Q15835
Weight	63 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: GRK1 polyclonal antibody detects endogenous levels of GRK1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:2000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11306069	BS7127	50µl	$234.89		Add to Cart
BHA11306069	BS7127	100µl	$368.22		Add to Cart

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