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Home / Antibodies

Anti-GJA3 Antibody BHA11304111

SKU : BHA11304111

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Mfr.No.	BS61194
Alternative Names	Gap junction alpha-3 protein ; Connexin-46 ; Cx46 ; GJA3
Antigen	GJA3
Categories	Primary Antibodies
Chromosome Location	13q12.11
Clonality	polyclonal
Description	The connexin family of proteins form hexameric complexes called “connexons” that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane α-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions. Each of the approximately 20 connexin isoforms produces channels with distinct permeabilities and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for another. Consequently, a wide variety of malignant phenotypes associate with decreased connexin expression and gap junction communication, dependent on the particular connexin that is affected. For instance, deletion of the gene encoding connexin 46, normally expressed in the lens, produces severe cataracts.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human GJA3.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q9Y6H8
Uniprot	Q9Y6H8
Weight	47 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: GJA3 polyclonal antibody detects endogenous levels of GJA3 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304111	BS61194	50µl	$190.44		Add to Cart
BHA11304111	BS61194	100µl	$294.44		Add to Cart

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