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Home / Antibodies

Anti-GEMIN2 Antibody BHA11303404

SKU : BHA11303404

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Mfr.No.	BS60255
Alternative Names	Gem-associated protein 2 ; Gemin-2 ; Component of gems 2 ; Survival of motor neuron protein-interacting protein 1 ; SMN-interacting protein 1 ; GEMIN 2 ; SIP1
Categories	Primary Antibodies
Chromosome Location	14q21.1
Clonality	polyclonal
Description	Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord. SMA is caused by deletion or loss-of-function mutations in the SMN (survival of motor neuron) gene. Gemin2 (formerly known as SIP1 for SMN interacting protein) associates directly with SMN and is a part of the SMN complex containing Gemin3 (a DEAD-box RNA helicase), Gemin4, Gemin5 and Gemin6, as well as several spliceosomal snRNP proteins. The SMN complex plays an essential role in splicesomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus. It is found in both the cytoplasm and the nucleus. The nuclear form is concentrated in subnuclear bodies called gems (Gemini of the coiled bodies). The SMN-Gemin2 complex is associated with spliceosomal snRNAs U1 and U5. Gemin2 is expressed in spinal cord. It can be induced by TGFβ treatment and expression is high in several E-cadherin negative human carcinoma cell lines.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human GEMIN2.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O14893
Uniprot	O14893
Weight	31 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: GEMIN2 polyclonal antibody detects endogenous levels of GEMIN2 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303404	BS60255	50µl	$190.44		Add to Cart
BHA11303404	BS60255	100µl	$294.44		Add to Cart

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