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Home / Antibodies

Anti-GBP1 Antibody BHA11301732

SKU : BHA11301732

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Mfr.No.	BS3028
Alternative Names	Interferon-induced guanylate-binding protein 1 ; GTP-binding protein 1 ; GBP-1 ; HuGBP-1 ; Guanine nucleotide-binding protein 1 ; GBP1
Antigen	GBP1
Categories	Primary Antibodies
Chromosome Location	1p22.2
Clonality	polyclonal
Description	GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage step, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-γ during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi’s sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 80-130 of Human GBP1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P32455
Uniprot	P32455
Weight	68 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: GBP1 (E99) polyclonal antibody detects endogenous levels of GBP1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IF

Description

WB ; IF

Dilution

WB	1:500-1:1000
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11301732	BS3028	50µl	$190.44		Add to Cart
BHA11301732	BS3028	100µl	$294.44		Add to Cart

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