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Home / Antibodies

Anti-EWSR1 Antibody BHA11302940

SKU : BHA11302940

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Mfr.No.	BS5715
Alternative Names	RNA-binding protein EWS ; EWS oncogene ; Ewing sarcoma breakpoint region 1 protein ; EWS
Categories	Primary Antibodies
Chromosome Location	22q12.2
Clonality	polyclonal
Description	EWS is a nuclear RNA-binding protein. As a result of chromosome translocation, the EWS gene is fused to a variety of transcription factors, including ATF-1 in human neoplasias. In the Ewing family of tumors, the N-terminal domain of EWS is fused to the DNA-binding domain of various ETS transcription factors, including Fli-1, Erg, ETV1, E1AF and FEV. The EWS/Fli-1 chimeric protein acts as a more potent transcriptional activator than Fli-1 and can promote cell transformation. Two functional regions have been identified in EWS; an amino-terminal region (domain A), that has little transactivation activity but transforms efficiently when fused to Fli-1, and a distal region (domain B), which shows transactivation activity but transforms less efficiently when fused to Fli-1.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to the 465-510 of Human EWSR1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q01844
Uniprot	Q01844
Weight	68, 90 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: EWSR1 polyclonal antibody detects endogenous levels of EWSR1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302940	BS5715	50µl	$190.44		Add to Cart
BHA11302940	BS5715	100µl	$294.44		Add to Cart

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