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Home / Primary Antibodies / IHC Antibodies

Anti-DGKE Antibody BHA11301275

SKU : BHA11301275

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Mfr.No.	BS2281
Alternative Names	Diacylglycerol kinase epsilon ; DAG kinase epsilon ; Diglyceride kinase epsilon ; DGK-epsilon ; DGKE ; DAGK5
Antigen	DGKE
Categories	Primary Antibodies
Chromosome Location	17q22
Clonality	polyclonal
Description	Diacylglycerol (DAG) influences numerous cell signaling cascades by functioning as an intracellular, allosteric activator of protein kinase C (PKC), and as a potent activator of guanine nucleotide exchange factors. In order to maintain cellular homeostasis, intracellular DAG levels are tightly regulated by diacylglycerol kinases (DGKs, DAGKs), which phosphorylate DAG to phosphatidic acid, thus removing DAG. Human DGK-α (80 kDa), -β (90 kDa), and -γ (90 kDa) have calcium-binding EF-hand motifs at their N termini and are classified as type I DGKs. Human DGK-δ (130 kDa) and DGK-i (130 kDa) contain N-terminal pleckstrin homology (PH) domains and are classified as type II. Human DGK-ε (64 kDa) contains no identifiable regulatory domains and is classified as a type III DGK. Human DGK-ζ (104 kDa) and -iota (130 kDa) possess C-terminal ankyrin repeats and are classified as type IV DGKs. Human DGK-θ (110 kDa) contains 3 cysteine-rich domains and a PH domain and is classified as a type V DGK.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 180-230 of Human DGK-ε.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P52429
Uniprot	P52429
Weight	64 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: DGK-ε (S194) polyclonal antibody detects endogenous levels of DGK-ε protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

IHC

Description

IHC

Dilution

IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11301275	BS2281	50µl	$190.44		Add to Cart
BHA11301275	BS2281	100µl	$294.44		Add to Cart

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