Encoded by the KRT19 gene, Cytokeratin 19 along with other members of the keratin family is responsible for the structural integrity of epithelial cells and the organization of myofibers. It is also involved in linking the contractile apparatus to dystrophin at the costameres of striated muscles. Lung cancer and thyroid cancer are the diseases associated with mutations in the KRT19. The Anti-Cytokeratin 19 Antibody also reacts with a wide variety of simple epithelia and non-squamous stratified epithelia. It does not react with stratified squamous epithelia. However, cervical squamous cell carcinomas show positivity with this antibody.
Host
Mouse
Immunogen
Keratin fraction isolated from Human Breast Cancer MCF-7 cells
Isotype
IgG2a
Reactivity
Rat, Mouse, Human
Recombinant
TRUE
Regulatory
RUO
Buffer
PBS, pH 7.4 with 0.05% sodium azide
Concentration
100µg/100µl
Description
Specificity: Human Cytokeratin 19.
Format
Liquid
Purity
The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.
Storage
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.