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Home / Antibodies

Anti-CYP8B1 Antibody BHA11303459

SKU : BHA11303459

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Mfr.No.	BS60310
Alternative Names	7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase ; 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase ; CYPVIIIB1 ; Cytochrome P450 8B1 ; Sterol 12-alpha-hydroxylase ; CYP8B1 ; CYP12
Categories	Primary Antibodies
Chromosome Location	3p22.1
Clonality	polyclonal
Description	CYP8B1 (sterol 12-α-hydroxylase) is a member of the cytochrome P450 superfamily of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. CYP8B1 is highly expressed in liver and is an important enzyme for bile acid synthesis. Specifically, CYP8B1 moderates the ratio of cholic acid over chenodeoxycholic acid to control the solubility of cholesterol. The gene encoding human CYP8B1 maps to chromosome 3p22.1. The CYP8B1 gene encodes a 501 amino acid protein and does not contain any introns. The CYP8B1 gene promoter is transactivated by hepatocyte nuclear factor 4α. In mice, disruption of the CYP8B1 gene prevents the synthesis of cholate, which is a primary bile acid.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human CYP8B1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q9UNU6
Uniprot	Q9UNU6
Weight	58 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: CYP8B1 polyclonal antibody detects endogenous levels of CYP8B1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303459	BS60310	50µl	$190.44		Add to Cart
BHA11303459	BS60310	100µl	$294.44		Add to Cart

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