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Home / Antibodies

Anti-CD19 Antibody BHA11304573

SKU : BHA11304573

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Mfr.No.	BS61805
Alternative Names	B-lymphocyte antigen CD19 ; B-lymphocyte surface antigen B4 ; Differentiation antigen CD19 ; T-cell surface antigen Leu-12 ; CD19
Categories	Primary Antibodies
Chromosome Location	16p11.2
Clonality	polyclonal
Description	CD19 is a 95 kDa coreceptor, which amplifies the signaling cascade in B cells . On the B cell surface, CD19 associates with CD21, CD81 and Leu-13 to exert its function. The cytoplasmic tail of CD19 has nine conserved tyrosine residues playing critical roles in CD19 mediated function by coupling signaling molecules to the receptor . After B cell receptor or CD19 ligation, Tyr531 and Tyr500 of CD19 are progressively phosphorylated. This phosphorylation enables the coupling of PI3 kinase and Src family tyrosine kinase to CD19 and activates the PI3K and Src signaling pathways. Coligation of B cell receptor and CD19 also promotes Tyr409 phosphorylation in CD19. The phosphorylation at these sites enables its binding to Vav and mediates elevated intracellular calcium response, as well as the JNK pathway.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to Human CD19.
Reactivity	Human, Rat, Mouse
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P15391
Uniprot	P15391
Weight	95 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: CD19 pAb detects endogenous levels of CD19 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304573	BS61805	50µl	$190.44		Add to Cart
BHA11304573	BS61805	100µl	$294.44		Add to Cart

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