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Home / Antibodies

Anti-CALCA Antibody BHA11303628

SKU : BHA11303628

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Mfr.No.	BS60494
Alternative Names	Calcitonin gene-related peptide 1 ; Alpha-type CGRP ; Calcitonin gene-related peptide I ; CGRP-I ; CALCA ; CALC1
Antigen	CALCA
Categories	Primary Antibodies
Clonality	polyclonal
Description	Calcitonin is a 32 amino acid polypeptide hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides, Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin gene-related peptide 1, also designated CGRP1 or å-CGRP. CGRP is a widely distributed vasodilatory peptide. Calcitonin and katacalcin are produced primarily in the thyroid, while CGRP is produced in neuronal cells. A second CGRP related gene, CALCB, thought to be derived from an gene duplication event, has been identified in mouse, rat and human. Unlike CALCA, CALCB is not subject to alternative splicing and encodes a single transcript designated CGRP2 or β-CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human CALCA.
Reactivity	Human, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	P06881/P01258
Uniprot	P06881/P01258
Weight	13 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: CALCA polyclonal antibody detects endogenous levels of CALCA protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303628	BS60494	50µl	$190.44		Add to Cart
BHA11303628	BS60494	100µl	$294.44		Add to Cart

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