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Home / Antibodies

Anti-CAGE1 Antibody BHA11304294

SKU : BHA11304294

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Mfr.No.	BS61541
Alternative Names	Cancer-associated gene 1 protein ; CAGE-1 ; Cancer/testis antigen 3 ; CT3
Antigen	CAGE1
Categories	Primary Antibodies
Chromosome Location	6p24.3
Clonality	polyclonal
Description	Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 718-762 of Human CAGE1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q8TC20
Uniprot	Q8TC20
Weight	90 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: CAGE1 polyclonal antibody detects endogenous levels of CAGE1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304294	BS61541	50µl	$190.44		Add to Cart
BHA11304294	BS61541	100µl	$294.44		Add to Cart

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