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Home / Primary Antibodies / Monoclonal Antibodies

Anti-BCMA-Anti-CD3 Bispecific Antibody

SKU : BHA18200044

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BPS Bioscience

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Mfr.No.	100689-1
Background	B-cell maturation antigen (BCMA), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein encoded by the TNFRSF17 gene. TNFRSF17 is a cell surface receptor of the TNF receptor superfamily that recognizes B-cell activating factor (BAFF). BCMA is preferentially expressed in mature B lymphocytes and also on Multiple Myeloma (MM) cells. Upregulations of BCMA also correlates with disease burden and pro prognosis in multiple myeloma. This bispecific antibody binds to BCMA on cancer cells and CD3 on T cells simultaneously, thus bringing T lymphocytes closer to the cancer cells. The binding event potentiates unstimulated T cells and induces direct cytotoxicity against BCMA+ cancer cells.
Clonality	Monoclonal (Bispecific)
Description	Anti-BCMA-Anti-CD3-Avi-His-Tag is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in both ELISA binding assay to BCMA-biotin and functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of BCMA-CHO cells (BPS Bioscience #79500-H).
Formulation	8 mM phosphate, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol
Instructions for use	See data sheet for detailed protocol
Molecular Weight	57 kDa
Species	Human
Tag	C-terminal Avi-His-Tag
Note	This product is for research use only. It is not suitable for human diagnostic or therapeutic use. Avoid freeze/thaw cycles.

Format	Aqueous buffer solution.
Purification	Ni-NTA affinity purification of the His-tag protein from HEK293 cells.
Shipping Temperature	-80°C (dry ice)
Storage Stability	Stable for at least 12 months at -80°C. Avoid freeze/thaw cycles.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA18200044	100689-1	50 ug	$379.50		Add to Cart

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