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Home / Antibodies

Anti-ATP6V0A2 Antibody BHA11303852

SKU : BHA11303852

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Mfr.No.	BS60737
Alternative Names	V-type proton ATPase 116 kDa subunit a isoform 2 ; V-ATPase 116 kDa isoform a2 ; Lysosomal H(+)-transporting ATPase V0 subunit a2TJ6 ; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 ; ATP6V0A2
Categories	Primary Antibodies
Chromosome Location	12q24.31
Clonality	polyclonal
Description	Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for the acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and an integral V0 domain, which is responsible for proton translocation, comprise the V-ATPase complex. Nine subunits (A–H) make up the V1 domain and five subunits (A, D, C, C' and C") make up the V0 domain. As part of the V0 domain, V-ATPase A2 (ATPase, H+ transporting, lysosomal V0 subunit a2), consists of 856 amino acids and is also known as ATP6V0A2, V-type proton ATPase subunit a isoform 2, vacuolar proton translocating ATPase subunit a isoform 2, lysosomal H(+)-transporting ATPase V0 subunit a2 or TJ6. V-ATPase A2 is a multi-pass membrane protein with localization in the cell membrane, endosome membrane and the subapical vesicles of the kidney’s proximal tubules. V-ATPase A2 plays an important role in Golgi function by regulating pH. Wrinkly skin syndrome (WSS) and cutis laxa type II (ARCL type II) are caused as a result of V-ATPase A2 defects.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human ATP6V0A2.
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q9Y487
Uniprot	Q9Y487
Weight	98 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.10. Specificity: ATP6V0A2 polyclonal antibody detects endogenous levels of ATP6V0A2 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 102% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -27°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000
IHC	1:50-1:207

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303852	BS60737	50µl	$190.44		Add to Cart
BHA11303852	BS60737	100µl	$294.44		Add to Cart

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