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Home / Antibodies

Anti-APOBEC3F/APOBEC3D Antibody BHA11304481

SKU : BHA11304481

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Mfr.No.	BS61718
Alternative Names	DNA dC->dU-editing enzyme APOBEC-3D ; A3D ; APOBEC3D ; DNA dC->dU-editing enzyme APOBEC-3F ; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F ; A3F ; APOBEC3F
Antigen	APOBEC3F/APOBEC3D
Categories	Primary Antibodies
Clonality	polyclonal
Description	DNA dC->dU-editing enzyme APOBEC-3D/3F, DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 220-270 of Human APOBEC3D.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q96AK3/Q8IUX4
Uniprot	Q96AK3/Q8IUX4
Weight	45 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: APOBEC3D/APOBEC3F polyclonal antibody detects endogenous levels of APOBEC3D/APOBEC3F protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304481	BS61718	50µl	$190.44		Add to Cart
BHA11304481	BS61718	100µl	$294.44		Add to Cart

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