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Home / Antibodies

Anti-2019-nCoV Spike Neutralizing Antibody

SKU : BHA10324226

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	E-AB-V1024
Background	Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Host	Mouse
Immunogen	0
Isotype	IgG1
Reactivity	SARS-COV2

Clone No	4A3

Buffer	0.2 um filtered solution in PBS
Concentration	1 mg/mL
Purification	Protein A affinity purification
Storage	Store at -20?. Avoid freeze / thaw cycles.

Applications	Neutralization, ELISA
Dilution	ELISA: 1:1,000-1:2,000

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA10324226	E-AB-V1024	50?L	$390		Add to Cart
BHA10324226	E-AB-V1024	100ul	$650		Add to Cart

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