Calcium-activated chloride channel(CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors(OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.
Categories
Primary Antibodies
Cellular Localization
Membrane
Clonality
polyclonal
Description
Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.
Host
Rabbit
Immunogen
anoctamin 2
Isotype
IgG
Molecular Weight
114 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Cell membrane
Synonyms
ANO2, anoctamin 2, C12orf3, DKFZp434P102, TMEM16B, Transmembrane protein 16B
Uniprot
Q9NQ90
Gene Id
57101
Research Area
Neuroscience
Weight
114kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)