Mouse Anti-Human Ankyrin R Monoclonal IgG2B

Mfr.No.	SMC-487, SMC-487D, SMC-487D-A390, SMC-487D-A488, SMC-487D-A594, SMC-487D-ALP, SMC-487D-APC, SMC-487D-BI, SMC-487D-FITC, SMC-487D-HRP, SMC-487D-PCP, SMC-487D-RPE, SMC-487S
Immunogen Species	Human
Alternative Names	Ankyrin-R Antibody, Ankyrin-1 Antibody, Erythrocyte Ankyrin Antibody, ANK-1 Antibody, ANK Antibody, rCG_43073 Antibody
Categories	Antibodies
Cellular Localization	Cytoskeleton, Cytoplasm, Myofibril, Sarcomere, M line
Certificate Of Analysis	A 1:100 dilution of SMC-487 was sufficient for detection of Ankyrin R in 20 ug of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Human Ankyrin R Monoclonal IgG2B
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R, Homo Sapiens (Human)
Immunogen Region	Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R
Isotype	IgG2B
Launch Date	2015/03/10
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	P16157
Accession Number	NP_000028.3
Gene Id	286
Target	Ankyrin R
Clone No	S388A-10
Research Area	Cell Markers, Neuron Markers, Membrane Markers, Cell Signaling, Scaffold Proteins, Cardiovascular System, Blood, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. Ankyrin R, or Ank1, was first discovered in erythrocyres, but has since also been located in the brain and muscles. Mutations are associated with hereditary spehrocytosis and alzheimer's diease (2).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~200kDa. Does not cross-react with Ankyrin-B or Ankyrin-G.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:1000); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 135392. 2. Genes and mapped phenotypes. (n.d.). Retrieved April 21, 2015, from http://www.ncbi.nlm.nih.gov/gene/286

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11905122-1	SMC-487D	Unconjugated	100 ug	$330	Add to Cart
BHA11905122-2	SMC-487D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11905122-3	SMC-487D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11905122-4	SMC-487D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11905122-5	SMC-487D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11905122-6	SMC-487D-APC	APC	100 ug	$382	Add to Cart
BHA11905122-7	SMC-487D-BI	Biotin	100 ug	$378	Add to Cart
BHA11905122-8	SMC-487D-FITC	FITC	100 ug	$374	Add to Cart
BHA11905122-9	SMC-487D-HRP	HRP	100 ug	$370	Add to Cart
BHA11905122-10	SMC-487D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11905122-11	SMC-487D-RPE	RPE	100 ug	$380	Add to Cart
BHA11905122-12	SMC-487S	Unconjugated	12 ug	$44	Add to Cart

Ankyrin R Antibody, Clone S388A-10 - SMC-487