ANGPTL2(angiopoietin-like 2), a member of the Angptl protein family, is predominantly secreted from adipose tissue and the heart. ANGPTL2 consists of an N-terminus with a conserved coiled-coil domain, two glycosylation sites and a C-terminus with a conserved fibrinogen-like domain. It is a key adipocyte-derived inflammatory mediator that links obesity to systemic insulin resistance. ANGPTL2 may play an important role in the pathogenesis of diabetic glomerulopathy.
Categories
Primary Antibodies
Cellular Localization
Secreted
Clonality
polyclonal
Description
ANGPTL2 (angiopoietin-like 2), a member of the Angptl protein family, is predominantly secreted from adipose tissue and the heart. ANGPTL2 consists of an N-terminus with a conserved coiled-coil domain, two glycosylation sites and a C-terminus with a conserved fibrinogen-like domain. It is a key adipocyte-derived inflammatory mediator that links obesity to systemic insulin resistance. ANGPTL2 may play an important role in the pathogenesis of diabetic glomerulopathy.
Host
Rabbit
Immunogen
angiopoietin 2
Isotype
IgG
Molecular Weight
57 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Secreted
Synonyms
Angiopoietin like 2, Angiopoietin like protein 2, Angiopoietin related protein 2, ANGPTL2, ARP2, HARP
Uniprot
O15123
Research Area
Developmental biology, Immunology, Cardiovascular, Signal Transduction
Weight
51kDa,57kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)