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Home / Primary Antibodies / Polyclonal Antibodies

Amphiregulin antibody

SKU : BHA10810342

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Mfr.No.	FNab10384
Background	Amphiregulin(AREG) is one of the ligands of the epidermal growth factor receptor(EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs. Post-translastional modfications of 50-kDa pro-AREG produces a major soluble 43-kDa form, 28-, 26-, 16-kDa membrane anchored forms, and soluble 21-, 19-, and 9-kDa forms(PMID: 9642297).
Clonality	polyclonal
Host	Rabbit
Immunogen	amphiregulin
Immunogen Region	amphiregulin
Isotype	IgG
Molecular Weight	43-50 kDa
Reactivity	Human, Rat
Recommended Dilution	WB: 1:200-1:2000; IHC: 1:50-1:500
Subcellular Location	Membrane
Synonyms	Amphiregulin, AR, AREG, AREGB, CRDGF, SDGF

Uniprot	P15514
Gene Id	374
Research Area	Immunology, Cardiovascular, Signal Transduction

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:200-1:2000; IHC: 1:50-1:500

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10384.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810342	FNab10384	100ug	$240		Add to Cart

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