Mouse Anti-Human AMIGO-1 Monoclonal IgG1

Mfr.No.	SMC-438, SMC-438D, SMC-438D-A390, SMC-438D-A488, SMC-438D-A594, SMC-438D-ALP, SMC-438D-APC, SMC-438D-BI, SMC-438D-FITC, SMC-438D-HRP, SMC-438D-PCP, SMC-438D-RPE, SMC-438S
Immunogen Species	Mouse
Alternative Names	AMIGO 1 Antibody, AMIGO1 Antibody, Adhesion molecule with Ig like domain 1 Antibody, Amphoterin-induced protein 1 Antibody, Alivin-2 Antibody, Alivin 2 Antibody, Ali2 Antibody, AMIGO Antibody, KIAA1163 Antibody, Amphoterin induced gene and ORF (Amigo) Antibody, Amphoterin induced protein 1 Antibody, MGC25558 Antibody, OTTHUMP00000013379 Antibody, RP23 89M15.6 Antibody
Categories	Antibodies
Cellular Localization	Cell Membrane, Cell Projection, Axon
Certificate Of Analysis	1 ug/ml of SMC-438 was sufficient for detection of AMIGO-1 in 20 ug of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Mouse AMIGO-1 Monoclonal IgG1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 554-574 (cytoplasmic C-terminus) of human AMIGO-1, Homo Sapiens (Human)
Immunogen Region	Fusion protein amino acids 394-492 (cytoplasmic C-terminus) of mouse AMIGO-1
Isotype	IgG1
Launch Date	2013/02/05
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	Q80ZD8
Accession Number	NP_001004293.1
Gene Id	229715
Target	AMIGO1
Clone No	S86-36
Research Area	Cell Markers, Neuron Markers, Presynaptic Markers, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO1, AMIGO2 and AMIGO3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. They can form complexes with each other, but can also self-bind. AMIGO1, also designated Alivin2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO2 (Alivin1) is crucial for depolarization-dependent survival. Similar to AMIGO1 and AMIGO2, AMIGO3 (Alivin3) plays a role in hemophilic and/or heterophilic cell-cell interaction and signal transduction.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~60-80kDa depending on maturity/glycosylation.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:1000); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Kuja-Panula J., Kiiltomäki M., Yamashiro T., Rouhiainen A. and Rauvala H. (2003) J. Cell Biol. 160: 963-973. 2. Clark H.F., et al. (2003) Genome Res. 13: 2265-2270. 3. On, T., Sekino-Suzuki N., Kikkawa Y., Yonekawa H. and Kawashima S. (2003) J. Neurosci. 23: 5887-5896. 4. Chen Y., Aulia S., Li L. and Tang B.L. (2006) Brain Res. Brain Res. Rev. 51: 265-274.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11904229-1	SMC-438D	Unconjugated	100 ug	$330	Add to Cart
BHA11904229-2	SMC-438D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11904229-3	SMC-438D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11904229-4	SMC-438D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11904229-5	SMC-438D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11904229-6	SMC-438D-APC	APC	100 ug	$382	Add to Cart
BHA11904229-7	SMC-438D-BI	Biotin	100 ug	$378	Add to Cart
BHA11904229-8	SMC-438D-FITC	FITC	100 ug	$374	Add to Cart
BHA11904229-9	SMC-438D-HRP	HRP	100 ug	$370	Add to Cart
BHA11904229-10	SMC-438D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11904229-11	SMC-438D-RPE	RPE	100 ug	$380	Add to Cart
BHA11904229-12	SMC-438S	Unconjugated	12 ug	$44	Add to Cart

AMIGO1 Antibody, Clone S86-36 - SMC-438