Rabbit Anti-Human Alpha Synuclein pSer129 Monoclonal IgG

Mfr.No.	SMC-600, SMC-600D, SMC-600D-A390, SMC-600D-A488, SMC-600D-A594, SMC-600D-ALP, SMC-600D-APC, SMC-600D-BI, SMC-600D-FITC, SMC-600D-HRP, SMC-600D-PCP, SMC-600D-RPE, SMC-600S
Immunogen Species	Human
Alternative Names	Phosphorylated alpha synuclein antibody, Phospho anti-alpha Synuclein (S129) antibody, Alpha-synuclein (phospho S129) antibody, alpha Synuclein (phospho Ser129) antibody, alpha-Synuclein Phospho Ser129 Antibody, phospho-alpha-Synuclein (Ser129) Antibody, Alpha synuclein antibody, Alpha synuclein antibody phospho Serine 129, Alpha synuclein antibody phospho Ser 129, Alpha synuclein antibody pSerine 129, Alpha synuclein antibody pSer 129, Alpha synuclein antibody phosphoSer 129, Alpha-synuclein antibody, Alpha-synuclein, isoform NACP140 antibody, alphaSYN antibody, NACP antibody, Non A beta component of AD amyloid antibody, Non A4 component of amyloid antibody, Non A4 component of amyloid precursor antibody, Non-A beta component of AD amyloid antibody, Non-A-beta component of alzheimers disease amyloid , precursor of antibody, Non-A4 component of amyloid precursor antibody, Non-A4 component of amyloid, precursor of antibody, PARK 1 antibody, PARK 4 antibody, PARK1 antibody, PARK4 antibody, Parkinson disease (autosomal dominant, Lewy body) 4 antibody, Parkinson disease familial 1 antibody, SNCA antibody, alpha (non A4 component of amyloid precursor) antibody, SYN antibody, Synuclein alpha antibody, Synuclein alpha 140 antibody, Synuclein, alpha (non A4 component of amyloid precursor) antibody, SYUA_HUMAN antibody
Antigen	Alpha Synuclein
Categories	Antibodies
Cellular Localization	Cytoplasm, Cytosol, Membrane, Nucleus, Cell Junction, Synapse
Certificate Of Analysis	A 1:500 dilution of SMC-600 was sufficient for detection of Alpha Synuclein pSer129 in 10 ug of Mouse Brain by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Conjugate	Unconjugated, ATTO 390, ATTO 488, ATTO 594, Alkaline Phosphatase, APC, Biotin, FITC, HRP, PerCP, RPE
Description	Rabbit Anti-Human Alpha Synuclein pSer129 Monoclonal IgG
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen Region	Human alpha synuclein AA 124-134: AYEMP-pS-EEGYQ-Cys
Isotype	IgG
Launch Date	2019/08/14
Net Weight (g)	0.1
Reactivity	Human, Mouse
Species Reactivity Medium	Mouse, Human
Tissue Specificity	Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.

Swissprot	P37840
Accession Number	NP_000336.1
Gene Id	6622
Clone No	J18
Research Area	Tangles & Tau, Multiple System Atrophy, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Synuclein, Neuroscience

Buffer	PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide
Concentration	1 mg/ml
Purification	Affinity Purified
Scientific Background	Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson s disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Alpha synuclein phosphorylated at serine 129 constitutes 90% of the alpha synuclein found in Lewy bodies (7, 8).
Shipping Temperature	Blue Ice or 4°C
Specificity	Binds to phosphorylated serine 129 on alpha synuclein. Does not detect unphosphorylated serine 129 alpha synuclein
Storage	-20ÂºC
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	ELISA, WB, ICC, IHC
Dilution	WB (1:500); optimal dilutions for assays should be determined by the user.

Product Manual	SDS

Reference	1. Genetics Home Reference: SNCA. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757. 7. Fujiwara H., et al. (2002) Nat Cell Biol. 4(2):160-4. 8. Anderson J.P., et al. (2006) J Biol Chem. 281(40):29739-52.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11933271-1	SMC-600D	Unconjugated	100 ug	$477	Add to Cart
BHA11933271-2	SMC-600D-A390	ATTO 390	100 ug	$530	Add to Cart
BHA11933271-3	SMC-600D-A488	ATTO 488	100 ug	$529	Add to Cart
BHA11933271-4	SMC-600D-A594	ATTO 594	100 ug	$529	Add to Cart
BHA11933271-5	SMC-600D-ALP	Alkaline Phosphatase	100 ug	$523	Add to Cart
BHA11933271-6	SMC-600D-APC	APC	100 ug	$528	Add to Cart
BHA11933271-7	SMC-600D-BI	Biotin	100 ug	$525	Add to Cart
BHA11933271-8	SMC-600D-FITC	FITC	100 ug	$520	Add to Cart
BHA11933271-9	SMC-600D-HRP	HRP	100 ug	$516	Add to Cart
BHA11933271-10	SMC-600D-PCP	PerCP	100 ug	$528	Add to Cart
BHA11933271-11	SMC-600D-RPE	RPE	100 ug	$526	Add to Cart
BHA11933271-12	SMC-600S	Unconjugated	12 ug	$44	Add to Cart

Alpha Synuclein Antibody (pSer129), Clone J18 - SMC-600

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