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Home / Primary Antibodies / Monoclonal Antibodies

Alpha Synuclein Antibody (Aggregate-Specific), Clone 2F11 - SMC-617

SKU : BHA11933476

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StressMarq Biosciences Inc.

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Mfr.No.	SMC-617, SMC-617, SMC-617D, SMC-617D-A390, SMC-617D-A488, SMC-617D-A594, SMC-617D-ALP, SMC-617D-APC, SMC-617D-BI, SMC-617D-FITC, SMC-617D-HRP, SMC-617D-PCP, SMC-617D-RPE, SMC-617S
Immunogen Species	Mouse
Alternative Names	Alpha Synuclein Antibody, Non-A beta component of AD amyloid Antibody, Non-A4 component of amyloid precursor Antibody, NACP Antibody, SNCA Antibody, PARK1 Antibody, PARK 1 Antibody, alphaSYN Antibody, PARK 4 antibody, PARK4 antibody, Parkinson disease familial 1 antibody, Parkinson disease (autosomal dominant, Lewy body) 4 antibody, SYN antibody
Categories	Antibodies
Cellular Localization	Cell Junction, Cytoplasm, Cytosol, Membrane, Nucleus, Synapse
Certificate Of Analysis	A 1:1000 dilution of SMC-617 was sufficient for detection of Alpha Synuclein aggregates in 15 ug of human brain cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Mouse Alpha Synuclein Aggregate Antibody Monoclonal IgG1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen Region	Mouse alpha synuclein fibrils
Isotype	IgG1
Launch Date	2023/11/03
Net Weight (g)	0.1
Reactivity	Human, Mouse
Species Reactivity Medium	Mouse, Human

Swissprot	O55042
Accession Number	NP_001035916.1
Gene Id	20617
Clone No	2F11
Research Area	Tangles & Tau, Multiple System Atrophy, Alzheimer's Disease, Neurodegeneration, Parkinson's Disease, Synuclein, Neuroscience

Concentration	1mg/ml
Purification	Protein G Purified
Scientific Background	Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimer s disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Covered by US patent family US11,098,108B2 (7).
Shipping Temperature	Blue Ice or 4°C
Specificity	Binds a 3-dimensional fibrillar epitope including AA101-120, AA61-80
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.09% sodium azide. *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	ICC-IF, ImmunoGold labelling, WB, DB, IP, IHC
Dilution	WB (1:1000). Application specific; optimal dilutions for assays should be determined by the user.

Product Manual	SDS

Reference	1. Genetics Home Reference: SNCA. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757. 7. Louwrier, A. US Patent family US11,098,108 B2

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Combination SKU	Supplier No.	Size	Conjugate	Your price	Quantity
BHA11933476-2	SMC-617D	100 ug	Unconjugated	$409		Add to Cart
BHA11933476-3	SMC-617D-A390	100 ug	ATTO 390	$458		Add to Cart
BHA11933476-4	SMC-617D-A488	100 ug	ATTO 488	$457		Add to Cart
BHA11933476-5	SMC-617D-A594	100 ug	ATTO 594	$457		Add to Cart
BHA11933476-6	SMC-617D-ALP	100 ug	Alkaline Phosphatase	$451		Add to Cart
BHA11933476-7	SMC-617D-APC	100 ug	APC	$456		Add to Cart
BHA11933476-8	SMC-617D-BI	100 ug	Biotin	$453		Add to Cart
BHA11933476-9	SMC-617D-FITC	100 ug	FITC	$449		Add to Cart
BHA11933476-10	SMC-617D-HRP	100 ug	HRP	$445		Add to Cart
BHA11933476-11	SMC-617D-PCP	100 ug	PerCP	$456		Add to Cart
BHA11933476-12	SMC-617D-RPE	100 ug	RPE	$454		Add to Cart
BHA11933476-13	SMC-617S	12 ug	Unconjugated	$40		Add to Cart

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