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Home / Primary Antibodies / Polyclonal Antibodies

alpha-synuclein antibody

SKU : BHA10800341

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Mfr.No.	FNab00345
Alternative Names	Alphasynuclein ; NACP ; PARK1 ; PARK4 ; SNCA
Background	Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Categories	Primary Antibodies
Cellular Localization	Widely
Clonality	polyclonal
Description	SNCA, also named as NACP, PARK1 and Alpha-synuclein, belongs to the synuclein family. It may be involved in the regulation of dopamine release and transport. SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. The deposition of aggregated SNCa is the pathological hallmark of Lewy body disease, which includes Parkinson's disease (PD), diffuse Lewy body disease (DLBD), and Lewy body variant of Alzheimer's disease (LBV).(PMID:21056999) This antibody can recognize all the isoforms of SNCA.
Host	Rabbit
Immunogen	synuclein, alpha (non A4 component of amyloid precursor)
Isotype	IgG
Molecular Weight	15 kDa
Reactivity	Human, Rat
Regulatory	RUO
Synonyms	Alpha synuclein, NACP, PARK1, PARK4, SNCA

Uniprot	P37840
Gene Id	6622
Research Area	Neuroscience
Weight	14kDa,observed 19kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, WB, IF

Description

ELISA ; IHC ; WB ; IF

Dilution

WB	1:500-1:5000
IF	1:10-1:100
IHC	1:20-1:200

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab00345.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800341	FNab00345	100ug	$260		Add to Cart

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