Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Clonality
monoclonal
Host
Mouse
Immunogen
synuclein, alpha (non A4 component of amyloid precursor)
Immunogen Region
synuclein, alpha (non A4 component of amyloid precursor)
Isotype
IgG1
Molecular Weight
18 kDa
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500 - 1:2000; IHC: 1:500 - 1:2000
Synonyms
Alpha synuclein, NACP, PARK1, PARK4, SNCA
Uniprot
P37840
Gene Id
6622
Clone No
5C6
Research Area
Neuroscience
Form
liquid
Purification
protein A+G purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500 - 1:2000; IHC: 1:500 - 1:2000
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab09891.pdf" target="_blank">Data Sheet</ a>