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Home / Primary Antibodies / Polyclonal Antibodies

Alpha E catenin antibody

SKU : BHA10800324

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Mfr.No.	FNab00327
Alternative Names	Alphacatenin ; AlphaEcatenin ; Cadherinassociatedprotein ; CAP102 ; Cateninalpha1 ; CTNNA1 ; α-catenin ; α-E-catenin ; αE-catenin
Background	This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, cytoskeleton, Membrane
Clonality	polyclonal
Description	Alpha catenin is an essential component of adherens junctions that connects E-cadherin-β-catenin complexes with the actin cytoskeleton. It also recruits a range of other important proteins to developing intercellular junctions. Three alpha catenins exist in human: alpha-E-catenin, alpha-N-catenin, and alpha-T-catenin, which share substantial amino-acid sequence similarity but have distinct tissue distribution. alpha-E-catenin is ubiquitously expressed, alpha-N-catenin is restricted to neuronal tissue, and alpha-T-catenin is primarily expressed in heart tissue. Reduced levels of alpha-E-catenin protein seem to be characteristic of many different human cancers, including malignant tumours of the breast, colon, stomach, oesophagus, bladder and liver. In addition, the loss of alpha-E-catenin often correlates with the degree of tumour differentiation and metastasis.
Host	Rabbit
Immunogen	Catenin alpha-1
Isotype	IgG
Molecular Weight	115 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Cytoskeleton,cell membrane
Synonyms	Alpha catenin, Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1, alpha-catenin, alpha-E-catenin, alphaE-catenin

Uniprot	P35221
Gene Id	1495
Research Area	Immunology
Weight	100kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IF, FC, IP

Description

ELISA ; WB ; IHC ; IF ; FC ; IP

Dilution

WB	1:1000-1:10000
IHC	1:20-1:200
IP	1:200-1:2000
IF	1:10-1:100

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IP: 1:50 - 1:100

Manual	FNab00327.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800324	FNab00327	100ug	$240		Add to Cart

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