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Home / Primary Antibodies / Monoclonal Antibodies

ALK,CD246 antibody

SKU : BHA10800308

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Mfr.No.	FNab00310
Alternative Names	ALK ; ALKtyrosinekinasereceptor ; ALK ; CD246 ; Anaplasticlymphomakinase ; CD246 ; TFG/ALK
Background	ALK, also named as CD246, is a receptor tyrosine kinase(RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM(Nucleophosmin)-ALK oncogenic fusion protein, resulting from the(2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma(ALCL). The EML4(echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer(NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC(PMID: 17625570).
Categories	Primary Antibodies
Cellular Localization	Membrane
Clonality	monoclonal
Description	ALK, also named as CD246, is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin)-ALK oncogenic fusion protein, resulting from the (2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL). The EML4 (echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer (NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC (PMID: 17625570).
Host	Mouse
Immunogen	anaplastic lymphoma receptor tyrosine kinase
Isotype	IgG2a
Molecular Weight	176 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Cell membrane, Membrane
Synonyms	ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK

Uniprot	Q9UM73
Gene Id	238
Clone No	2B10
Research Area	Developmental biology, Signal Transduction, Metabolism, Immunology, Cancer, Neuroscience
Weight	176kDa

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, WB

Description

ELISA ; IHC ; WB

Dilution

WB	1:500-1:5000
IHC	1:20-1:200

Tested Application

WB: 1:500-1:2000; IHC: 1:20-1:200

Manual	FNab00310.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800308	FNab00310	100ug	$260		Add to Cart

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