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Home / Primary Antibodies / Polyclonal Antibodies

ALCAM antibody

SKU : BHA10800278

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Mfr.No.	FNab00280
Alternative Names	ALCAM ; CD166 ; CD166antigen ; FLJ38514 ; MEMD
Background	Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts(PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6(PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6(PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM(PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow(PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction(PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions(PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation(By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons(By similarity). Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.
Categories	Primary Antibodies
Cellular Localization	Membrane, Secreted
Clonality	polyclonal
Description	Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.
Host	Rabbit
Immunogen	activated leukocyte cell adhesion molecule
Isotype	IgG
Molecular Weight	110 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Secreted, cell membrane
Synonyms	ALCAM, CD166, CD166 antigen, FLJ38514, MEMD

Uniprot	Q13740
Gene Id	214
Research Area	Developmental biology, Stem Cells, Immunology, Signal Transduction
Weight	65kDa,observed 110kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, WB

Description

ELISA ; IHC ; WB

Dilution

WB	1:200-1:2000
IHC	1:20-1:200

Tested Application

WB: 1:200-1:2000; IHC: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800278	FNab00280	100ug	$240		Add to Cart

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