Rabbit Anti-Mouse AHA1 Polyclonal

Mfr.No.	SPC-183, SPC-183D, SPC-183C, SPC-183D-A390, SPC-183D-A488, SPC-183D-A594, SPC-183D-ALP, SPC-183D-APC, SPC-183D-BI, SPC-183D-FITC, SPC-183D-HRP, SPC-183D-PCP, SPC-183D-RPE, SPC-183S
Immunogen Species	Mouse
Alternative Names	Activator of 90 kDa heat shock protein ATPase homolog 1 antibody, Activator of heat shock 90kDa protein ATPase homolog 1 antibody, AHA 1 antibody, AHA1 antibody, AHSA 1 antibody, AHSA1 antibody, AHSA1_HUMAN antibody, C14orf3 antibody, HSPC322 antibody, p38 antibody
Categories	Antibodies
Cellular Localization	Endoplasmic Reticulum, Cytoplasm
Certificate Of Analysis	1 ul/ml of SPC-183 was sufficient for detection of Aha1 in 10 ug of mixed human cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Mouse AHA1 Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Mouse Aha1, Mus Musculus (Mouse)
Immunogen Region	Recombinant Full Length Mouse Aha1 Protein
Launch Date	2009/06/01
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Mus Musculus (Mouse)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	Q8BK64
Accession Number	NP_666148.1
Gene Id	217737
Target	AHA1
Research Area	Cancer, Heat Shock, Cell Signaling, Chaperone Proteins, Protein Trafficking

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:60); optimal dilutions for assays should be determined by the user.
Purification	Protein A Purified
Scientific Background	Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~ 38kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	ELISA, IHC, IP, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF ; IP ; ELISA
Dilution	WB (1:1000), ICC/IF (1:60); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Hainzl O., Lapina M.C., Buchner J., Richter K. (2009) J Biol Chem. Epub. 2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3): 789-796. 3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121(pt.5): 717-723. 4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68(4): 1188-1197.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11907160-1	SPC-183D	Unconjugated	100 ul	$306	Add to Cart
BHA11907160-2	SPC-183C	Unconjugated	25 ul	$167	Add to Cart
BHA11907160-3	SPC-183D-A390	ATTO 390	100 ul	$360	Add to Cart
BHA11907160-4	SPC-183D-A488	ATTO 488	100 ul	$359	Add to Cart
BHA11907160-5	SPC-183D-A594	ATTO 594	100 ul	$359	Add to Cart
BHA11907160-6	SPC-183D-ALP	Alkaline Phosphatase	100 ul	$352	Add to Cart
BHA11907160-7	SPC-183D-APC	APC	100 ul	$358	Add to Cart
BHA11907160-8	SPC-183D-BI	Biotin	100 ul	$354	Add to Cart
BHA11907160-9	SPC-183D-FITC	FITC	100 ul	$350	Add to Cart
BHA11907160-10	SPC-183D-HRP	HRP	100 ul	$345	Add to Cart
BHA11907160-11	SPC-183D-PCP	PerCP	100 ul	$358	Add to Cart
BHA11907160-12	SPC-183D-RPE	RPE	100 ul	$355	Add to Cart
BHA11907160-13	SPC-183S	Unconjugated	12 ul	$44	Add to Cart

AHA1 Antibody - SPC-183