Mouse Anti-Human AHA1 Monoclonal IgG1 Kappa

Mfr.No.	SMC-198, SMC-198D, SMC-198D-A390, SMC-198D-A488, SMC-198D-A594, SMC-198D-ALP, SMC-198D-APC, SMC-198D-BI, SMC-198D-FITC, SMC-198D-HRP, SMC-198D-PCP, SMC-198D-RPE, SMC-198S
Immunogen Species	Human
Alternative Names	Aha 1 Antibody, Ahsa1 Antibody, p38 Antibody, HSPC322 Antibody, C14orf3 Antibody, Activator of HSP90 ATPase Antibody, Activator of 90 kDa heat shock protein ATPase homolog 1 Antibody
Categories	Antibodies
Cellular Localization	Endoplasmic Reticulum, Cytoplasm
Certificate Of Analysis	1 ug/ml of SMC-198 was sufficient for detection of Aha1 in 10 ug of HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Human AHA1 Monoclonal IgG1 Kappa
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Human Aha1, his tagged, Homo Sapiens (Human)
Immunogen Region	Human Aha1, his tagged
Isotype	IgG1 Kappa
Launch Date	2011/09/29
Net Weight (g)	0.1
Reactivity	Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Human

Swissprot	O95433
Accession Number	NP_036243.1
Gene Id	10598
Target	AHA1
Clone No	4H9-D7
Research Area	Cancer, Heat Shock, Cell Signaling, Chaperone Proteins, Protein Trafficking

Buffer	PBS pH7.2, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~38kDa, can run up to 45kDa on SDS Page. It sees human Aha1, Mouse Aha1 and Mouse Aha2.
Storage	-20ºC
Storage Buffer	PBS pH7.2, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	ELISA, WB, ICC/IF
Description	WB ; ICC ; IF ; ELISA
Dilution	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Hainzl O., Lapina M.C., Buchner J., Richter K. (2009) J Biol Chem. Epub. 2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3): 789-796. 3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121(pt.5): 717-723. 4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68(4): 1188-1197.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11901548-1	SMC-198D	Unconjugated	100 ug	$306	Add to Cart
BHA11901548-2	SMC-198D-A390	ATTO 390	100 ug	$360	Add to Cart
BHA11901548-3	SMC-198D-A488	ATTO 488	100 ug	$359	Add to Cart
BHA11901548-4	SMC-198D-A594	ATTO 594	100 ug	$359	Add to Cart
BHA11901548-5	SMC-198D-ALP	Alkaline Phosphatase	100 ug	$352	Add to Cart
BHA11901548-6	SMC-198D-APC	APC	100 ug	$358	Add to Cart
BHA11901548-7	SMC-198D-BI	Biotin	100 ug	$354	Add to Cart
BHA11901548-8	SMC-198D-FITC	FITC	100 ug	$350	Add to Cart
BHA11901548-9	SMC-198D-HRP	HRP	100 ug	$345	Add to Cart
BHA11901548-10	SMC-198D-PCP	PerCP	100 ug	$358	Add to Cart
BHA11901548-11	SMC-198D-RPE	RPE	100 ug	$355	Add to Cart
BHA11901548-12	SMC-198S	Unconjugated	12 ug	$44	Add to Cart

AHA1 Antibody, Clone 4H9-D7 - SMC-198