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Home / Antibodies

Acetyl-TP53 (K320) Antibody

BHA10542110
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
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Uniprot P04637
Gene Id 7157
Database Links

HGNC:11998

OMIM:133239

KEGG:hsa:7157

STRING:9606.ENSP00000269305

UniGene:Hs.437460
Function Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2
Pathway MAPK signaling pathway p53 signaling pathway PI3K-Akt signaling pathway Wnt signaling pathway Apoptosis Cell cycle Cellular senescence Cell ageing and metabolism Sphingolipid signaling pathway Neurotrophin signaling pathway
Protein Families P53 family
Tissue Specificity Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3
Weight 43.7kDa
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Format Liquid
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications WB, ELISA
Description WB ; ELISA
Dilution

WB1:500-1:2000
ELISA1:20000
Tested Application WB,ELISA;WB:1/500-1/2000.ELISA:1/20000
Datasheet
Western Blotting(WB) Protocol
ELISA Protocol
SKU Supplier No. Size Your price Quantity
BHA10542110 CSB-PA000140 100μg $168.78
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BHA10542110 CSB-PA000140 50μg $123
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