Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Categories
Primary Antibodies
Cellular Localization
Ecret, Membrane, Ytoplasm
Clonality
polyclonal
Description
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Host
Rabbit
Immunogen
angiotensin I converting enzyme(peptidyl-dipeptidase A) 1
Isotype
IgG
Molecular Weight
170 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Subcellular Location
Membrane,Cytoplasm,secret
Synonyms
ACE, ACE1, Angiotensin converting enzyme, CD143, DCP, DCP1, Dipeptidyl carboxypeptidase I, Kininase II, MVCD3
Uniprot
P12821
Gene Id
1636
Research Area
Immunology, Cardiovascular, Metabolism
Weight
150kDa,observed 170kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)