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Home / Primary Antibodies / Polyclonal Antibodies

ABCG2 Antibody - SPC-1317

BHA11917892
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Ask Merchant
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Swissprot Q9UNQ0
Accession Number NP_004818.2
Gene Id 9429
Target ABCG2
Research Area Tags and Cell Markers, Cell Signaling, Metabolism, Stem Cells, Hematopoietic Progenitors, HP Surface Molecules, Neural Stem Cells, Cancer, Cancer Metabolism, Drug Metabolism
Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Dilutions WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Scientific Background ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
Shipping Temperature Blue Ice or 4°C
Specificity Detects endogenous levels of total ABCG2
Storage -20ºC
Storage Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, WB
Description WB ; IHC
Dilution WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.

2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58.

3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41.

4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70.

5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9.

6. Miyake K., et al. (1999) Cancer Res. 59: 8-13.

7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11917892-1 SPC-1317D Unconjugated 100 ul $286
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BHA11917892-2 SPC-1317D-A390 ATTO 390 100 ul $340
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BHA11917892-3 SPC-1317D-A488 ATTO 488 100 ul $339
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BHA11917892-4 SPC-1317D-A594 ATTO 594 100 ul $339
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BHA11917892-5 SPC-1317D-BI Biotin 100 ul $334
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BHA11917892-6 SPC-1317D-FITC FITC 100 ul $330
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