ALOX5(arachidonate 5-lipoxygenase) is also named as LOG5, 5-LO and belongs to the lipoxygenase family. It catalyzes the first step in leukotriene biosynthesis, and plays a role in inflammatory processes. It is a 78 kDa iron-containing enzyme that translocates from the cytosol to associate with FLAP, and converts arachidonate in two steps into the unstable intermediate LTA4. It is essential for cysteinyl-leukotriene(cys-LT) production, critical mediators in asthma(PMID:12911785).
Categories
Primary Antibodies
Clonality
polyclonal
Description
ALOX5(arachidonate 5-lipoxygenase) is also named as LOG5, 5-LO and belongs to the lipoxygenase family. It catalyzes the first step in leukotriene biosynthesis, and plays a role in inflammatory processes. It is a 78 kDa iron-containing enzyme that translocates from the cytosol to associate with FLAP, and converts arachidonate in two steps into the unstable intermediate LTA4. It is essential for cysteinyl-leukotriene (cys-LT) production, critical mediators in asthma(PMID:12911785).
Host
Rabbit
Immunogen
arachidonate 5-lipoxygenase
Isotype
IgG
Molecular Weight
68-78 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
5 Lipoxygenase, 5 LO, 5 LOX, 5LPG, ALOX5, LOG5
Uniprot
P09917
Research Area
Metabolism
Weight
75kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)