Anti-undefined Antibody BCMA,2366 Unconjugated BHA10208111

Mfr.No.	608-MSM1-P1ABX
Alternative Names	B-cell maturation protein ; BCMA ; CD269 ; TNR17 ; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	16p13.13
Clonality	monoclonal
Description	The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).
Host	Mouse
Immunogen	Recombinant human CD269 protein fragment (around aa 78-184) (exact sequence is proprietary)
Isotype	IgG2b Kappa
Positive Control	NAMALWA Cells. Tonsil. Gastric Carcinoma
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q02223
Gene Id	608
Clone No	BCMA, 2366
Symbol	CD269
Weight	20kDa

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Applications

ELISA, IHC-F

Description

Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., ELISA ; IHC-F

Dilution