B-cell lymphoma 5 protein ; B-Cell Lymphoma 6 Protein ; BCL5 ; BCL6 ; BCL6A ; cys his2 zinc finger transcription factor ; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3) ; Zinc finger and BTB domain-containing protein 27 (ZBTB27) ; Zinc Finger Protein 51 (ZNF51) ; zinc finger transcription factor BCL6S
Antigen
Bcl-6
Categories
Primary Antibodies
Cellular Localization
Nuclear
Chromosome Location
3q27.3
Clonality
monoclonal
Conjugate
Unconjugated
Description
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ( L&H ) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Host
Mouse
Immunogen
Recombinant human bcl-6 protein fragment (around aa 256-389) (exact sequence is proprietary)
Isotype
IgG1 Kappa
Positive Control
Raji or Ramos cells. Tonsil
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Species
Homo Sapiens (Human)
Swissprot
P41182
Gene Id
604
Clone No
BCL6, 1475
Symbol
BCL6
Weight
95kDa
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Applications
WB
Description
Optimal dilution for a specific application should be determined., WB
Dilution
Western Blotting
1-2μg/ml
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Reviews of Anti-undefined Antibody BCL6,1475 Unconjugated BHA10208078