Anti-Thymidine Phosphorylase / PD-ECGF Antibody BHA10200853

Mfr.No.	1890-MSM1X-P1ABX
Alternative Names	ECGF ; ECGF1 ; Gliostatin ; hPD-ECGF ; MEDPS1 ; MNGIE ; MTDPS1 ; PD-ECGF ; PDECGF ; Platelet-derived endothelial cell growth factor
Categories	Primary Antibodies ; Phospho Antibodies
Cellular Localization	Cytoplasmic, Nuclear
Chromosome Location	22q13.33
Clonality	monoclonal
Description	Recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5 -deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
Host	Mouse
Immunogen	Recombinant full-length human Thymidine Phosphorylase (TP / PD-ECGF) protein
Isotype	IgG1
Positive Control	HUVEC cells. Breast, Bladder, Lung or Kaposi tumors
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	P19971
Uniprot	180903
Gene Id	1890

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

WB, IP, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., WB ; IP ; IHC-F

Dilution

WB	0.5-1μg/ml
IP	0.5-1 �g/500ug protein lysate
IHC-F	1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200853	1890-MSM1X-P1ABX	100µg	$393.20		Add to Cart

Anti-Thymidine Phosphorylase / PD-ECGF Antibody BHA10200853

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