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Home / Antibodies

Anti-TBK1 Antibody BHA11303831

SKU : BHA11303831

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Mfr.No.	BS60714
Alternative Names	Serine/threonine-protein kinase TBK1 ; NF-kappa-B-activating kinase ; T2K ; TANK-binding kinase 1 ; TBK1 ; NAK
Categories	Primary Antibodies
Chromosome Location	12q14.2
Clonality	polyclonal
Description	The transcription factor NFκB is retained in the cytoplasm in an inactive form by the inhibitory protein IκB. Activation of NFκB requires that IκB be phosphorylated on specific serine residues, which results in targeted degradation of IκB. IκB kinase α (IKKα), previously designated CHUK, interacts with IkB-a and specifically phosphorylates IκB-α on the sites that trigger its degradation, serines 32 and 36. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ (also designated NEMO), and each appear to make essential contributions to IκB phosphorylation. TANK binding kinase (TBK1), also designated T2K, is a novel IKK-related kinase that has been identified in murine and human tissues. TBK1 was shown to complex with TRAF2 and TANK in the NFκB activation pathway. TBK1 shares homology with IKKα and IKKβ in the amino-terminal half, which includes the kinase domain.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human TBK1
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q9UHD2
Uniprot	Q9UHD2
Weight	84 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: TBK1 polyclonal antibody detects endogenous levels of TBK1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303831	BS60714	50µl	$190.44		Add to Cart
BHA11303831	BS60714	100µl	$294.44		Add to Cart

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